| 19. Round | 30/01/2016 | SV Darmstadt 98 | - | FC Schalke 04 | 0:2 | ||||
| 20. Round | 06/02/2016 | FC Schalke 04 | - | VfL Wolfsburg | 3:0 |  |
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| 21. Round | 12/02/2016 | 1. FSV Mainz 05 | - | FC Schalke 04 | 2:1 | ||||
| 22. Round | 21/02/2016 | FC Schalke 04 | - | VfB Stuttgart | 1:1 |  |
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| 24. Round | 02/03/2016 | FC Schalke 04 | - | Hamburger SV | 3:2 | |
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| 25. Round | 05/03/2016 | 1. FC Köln | - | FC Schalke 04 | 1:3 | ||||
| 26. Round | 11/03/2016 | Hertha BSC | - | FC Schalke 04 | 2:0 | ||||
| 27. Round | 18/03/2016 | FC Schalke 04 | - | Bor. Mönchengladbach | 2:1 | ||||
| 28. Round | 02/04/2016 | FC Ingolstadt 04 | - | FC Schalke 04 | 3:0 | ||||
| 30. Round | 16/04/2016 | Bayern München | - | FC Schalke 04 | 3:0 | ||||
| 32. Round | 30/04/2016 | Hannover 96 | - | FC Schalke 04 | 1:3 | |
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| 33. Round | 07/05/2016 | FC Schalke 04 | - | FC Augsburg | 1:1 | ||||
| 34. Round | 14/05/2016 | 1899 Hoffenheim | - | FC Schalke 04 | 1:4 |
Austria