| 3. Round | 15/09/2018 | Bor. Mönchengladbach | - | FC Schalke 04 | 2:1 |  |
|||
| 4. Round | 22/09/2018 | FC Schalke 04 | - | Bayern München | 0:2 | ||||
| 5. Round | 25/09/2018 | SC Freiburg | - | FC Schalke 04 | 1:0 | ||||
| 6. Round | 29/09/2018 | FC Schalke 04 | - | 1. FSV Mainz 05 | 1:0 |  |
|
||
| 8. Round | 20/10/2018 | FC Schalke 04 | - | Werder Bremen | 0:2 | ||||
| 9. Round | 28/10/2018 | RB Leipzig | - | FC Schalke 04 | 0:0 | ||||
| 10. Round | 03/11/2018 | FC Schalke 04 | - | Hannover 96 | 3:1 | ||||
| 11. Round | 11/11/2018 | Eintracht Frankfurt | - | FC Schalke 04 | 3:0 | ||||
| 12. Round | 24/11/2018 | FC Schalke 04 | - | 1. FC Nürnberg | 5:2 | ||||
| 13. Round | 01/12/2018 | 1899 Hoffenheim | - | FC Schalke 04 | 1:1 | ||||
| 14. Round | 08/12/2018 | FC Schalke 04 | - | Borussia Dortmund | 1:2 | ||||
| 16. Round | 19/12/2018 | FC Schalke 04 | - | Bayer Leverkusen | 1:2 | ||||
| 17. Round | 22/12/2018 | VfB Stuttgart | - | FC Schalke 04 | 1:3 | |
|||
| 18. Round | 20/01/2019 | FC Schalke 04 | - | VfL Wolfsburg | 2:1 | ||||
| 19. Round | 25/01/2019 | Hertha BSC | - | FC Schalke 04 | 2:2 |
Austria