| 1. Round | 18/03/2018 | Sacramento Republic | - | San Antonio FC | 2:1 | ||||
| 2. Round | 28/04/2018 | Las Vegas Lights FC | - | San Antonio FC | 1:3 | ||||
| 3. Round | 06/05/2018 | San Antonio FC | - | Fresno FC | 2:1 |  |
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| 3. Round | 13/05/2018 | Rio Grande Valley FC | - | San Antonio FC | 0:0 | ||||
| 3. Round | 20/05/2018 | San Antonio FC | - | Tulsa Roughnecks | 1:1 | ||||
| 3. Round | 27/05/2018 | Reno 1868 FC | - | San Antonio FC | 2:1 | ||||
| 4. Round | 03/06/2018 | San Antonio FC | - | Portland Timbers 2 | 2:1 | |
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| 5. Round | 05/07/2018 | San Antonio FC | - | OKC Energy FC | 1:1 | |
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| 5. Round | 15/07/2018 | Orange County SC | - | San Antonio FC | 3:0 | ||||
| 5. Round | 26/07/2018 | San Antonio FC | - | Colorado Springs Switchbacks | 1:0 | ||||
| 6. Round | 12/08/2018 | Seattle Sounders 2 | - | San Antonio FC | 3:2 | ||||
| 6. Round | 16/08/2018 | Portland Timbers 2 | - | San Antonio FC | 2:1 | ||||
| 6. Round | 26/08/2018 | San Antonio FC | - | Swope Park Rangers | 1:2 |
England