| 3. Round | 28/07/2019 | San Lorenzo | - | Cerro Porteño | 2:1 | ||||
| 4. Round | 03/08/2019 | Deportivo Santaní | - | San Lorenzo | 1:1 | ||||
| 5. Round | 10/08/2019 | San Lorenzo | - | Deportivo Capiatá | 1:1 | ||||
| 6. Round | 16/08/2019 | San Lorenzo | - | General Díaz | 1:1 |  |
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| 7. Round | 24/08/2019 | Guaraní | - | San Lorenzo | 3:1 | ||||
| 8. Round | 01/09/2019 | San Lorenzo | - | Sol de América | 1:2 | ||||
| 9. Round | 15/09/2019 | Club Olimpia | - | San Lorenzo | 4:1 | ||||
| 11. Round | 24/09/2019 | River Plate | - | San Lorenzo | 0:0 | ||||
| 13. Round | 08/10/2019 | San Lorenzo | - | Sportivo Luqueño | 2:0 | ||||
| 14. Round | 20/10/2019 | Cerro Porteño | - | San Lorenzo | 2:0 | ||||
| 15. Round | 27/10/2019 | San Lorenzo | - | Deportivo Santaní | 3:2 |  |
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| 16. Round | 31/10/2019 | Deportivo Capiatá | - | San Lorenzo | 1:1 | |
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| 18. Round | 10/11/2019 | San Lorenzo | - | Guaraní | 0:0 | ||||
| 19. Round | 27/11/2019 | Sol de América | - | San Lorenzo | 1:0 | ||||
| 20. Round | 01/12/2019 | San Lorenzo | - | Club Olimpia | 1:4 | ||||
| 22. Round | 15/12/2019 | San Lorenzo | - | River Plate | 2:0 |
Paraguay