| 1. Round | 18/03/2017 | D.C. United | - | Columbus Crew | 0:2 | ||||
| 1. Round | 25/03/2017 | Columbus Crew | - | Portland Timbers | 3:2 | ||||
| 2. Round | 01/04/2017 | Columbus Crew | - | Orlando City | 2:0 | ||||
| 2. Round | 08/04/2017 | Chicago Fire | - | Columbus Crew | 1:0 |  |
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| 2. Round | 16/04/2017 | Columbus Crew | - | Toronto FC | 2:1 | ||||
| 2. Round | 23/04/2017 | New York RB | - | Columbus Crew | 2:0 | ||||
| 3. Round | 07/05/2017 | Columbus Crew | - | New England Revolution | 2:0 | ||||
| 3. Round | 11/05/2017 | Columbus Crew | - | Toronto FC | 1:2 | ||||
| 3. Round | 13/05/2017 | Impact de Montréal | - | Columbus Crew | 2:3 | ||||
| 3. Round | 01/06/2017 | Columbus Crew | - | Seattle Sounders | 3:0 | ||||
| 4. Round | 04/06/2017 | Colorado Rapids | - | Columbus Crew | 2:1 | ||||
| 5. Round | 05/07/2017 | Minnesota United FC | - | Columbus Crew | 0:1 | ||||
| 5. Round | 23/07/2017 | Columbus Crew | - | Philadelphia Union | 1:0 | ||||
| 5. Round | 27/07/2017 | Philadelphia Union | - | Columbus Crew | 3:0 | ||||
| 5. Round | 30/07/2017 | Real Salt Lake | - | Columbus Crew | 2:2 | ||||
| 6. Round | 06/08/2017 | San Jose Earthquakes | - | Columbus Crew | 2:1 | ||||
| 7. Round | 17/09/2017 | Vancouver Whitecaps | - | Columbus Crew | 2:2 |
USA
Italy