| 1. Round | 05/07/2015 | Guaraní | - | San Lorenzo | 0:1 |  |
|||
| 2. Round | 09/07/2015 | San Lorenzo | - | Club Nacional | 0:2 | ||||
| 3. Round | 18/07/2015 | Sol de América | - | San Lorenzo | 1:2 | ||||
| 4. Round | 25/07/2015 | San Lorenzo | - | Cerro Porteño | 1:1 | ||||
| 5. Round | 02/08/2015 | Deportivo Capiatá | - | San Lorenzo | 0:4 | ||||
| 6. Round | 09/08/2015 | San Lorenzo | - | Club Rubio Ñu | 1:1 | ||||
| 7. Round | 16/08/2015 | Deportivo Santaní | - | San Lorenzo | 2:1 | ||||
| 12. Round | 21/09/2015 | San Lorenzo | - | Guaraní | 2:2 | |
|||
| 13. Round | 29/09/2015 | Club Nacional | - | San Lorenzo | 0:2 | ||||
| 14. Round | 04/10/2015 | San Lorenzo | - | Sol de América | 2:4 | ||||
| 15. Round | 18/10/2015 | Cerro Porteño | - | San Lorenzo | 1:0 |  |
|||
| 18. Round | 04/11/2015 | San Lorenzo | - | Deportivo Santaní | 3:2 | ||||
| 19. Round | 07/11/2015 | San Lorenzo | - | General Díaz | 1:2 | |
|||
| 21. Round | 30/11/2015 | San Lorenzo | - | Sportivo Luqueño | 2:2 | ||||
| 22. Round | 05/12/2015 | Libertad | - | San Lorenzo | 1:1 |
Paraguay