1. Round | 18/07/2021 | Club Olimpia | - | River Plate | 1:3 | ||||
2. Round | 25/07/2021 | Guaireña FC | - | River Plate | 1:2 | ||||
3. Round | 31/07/2021 | River Plate | - | Cerro Porteño | 0:0 | ||||
4. Round | 09/08/2021 | Sol de América | - | River Plate | 1:0 | ||||
5. Round | 14/08/2021 | River Plate | - | Club Nacional | 1:0 | ||||
6. Round | 22/08/2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | ||||
7. Round | 30/08/2021 | River Plate | - | Guaraní | 1:5 | ||||
8. Round | 11/09/2021 | Sportivo Luqueño | - | River Plate | 0:2 | ||||
9. Round | 18/09/2021 | River Plate | - | Libertad | 0:1 | ||||
10. Round | 26/09/2021 | River Plate | - | Club Olimpia | 1:2 | ||||
12. Round | 19/10/2021 | Cerro Porteño | - | River Plate | 2:0 | ||||
13. Round | 23/10/2021 | River Plate | - | Sol de América | 0:2 | ||||
15. Round | 05/11/2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
18. Round | 03/12/2021 | Libertad | - | River Plate | 5:0 |