| 1. Round | 08/08/2020 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:2 | ||||
| 2. Round | 11/08/2020 | Slovan Bratislava | - | MFK Zemplín Michalovce | 5:0 | ||||
| 3. Round | 15/08/2020 | FK Senica | - | MFK Zemplín Michalovce | 3:0 | ||||
| 4. Round | 25/08/2020 | MFK Zemplín Michalovce | - | Zlaté Moravce | 1:0 | ||||
| 6. Round | 12/09/2020 | MFK Zemplín Michalovce | - | AS Trenčín | 1:1 |  |
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| 7. Round | 19/09/2020 | MFK Ružomberok | - | MFK Zemplín Michalovce | 4:0 | ||||
| 9. Round | 03/10/2020 | ŠKF Sereď | - | MFK Zemplín Michalovce | 1:1 | |
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| 10. Round | 17/10/2020 | MFK Zemplín Michalovce | - | FC DAC 1904 | 2:4 | ||||
| 18. Round | 16/12/2020 | MFK Zemplín Michalovce | - | MFK Ružomberok | 4:3 | |
Spain