| 2. Round | 21/01/2021 | Plaza Colonia | - | Progreso | 0:1 | ||||
| 3. Round | 30/01/2021 | Progreso | - | Liverpool | 0:4 | ||||
| 4. Round | 02/02/2021 | Progreso | - | Fénix | 0:1 | ||||
| 5. Round | 07/02/2021 | CA Cerro | - | Progreso | 2:0 | ||||
| 6. Round | 11/02/2021 | Progreso | - | Defensor Sporting | 3:3 |  |
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| 7. Round | 15/02/2021 | Danubio | - | Progreso | 0:1 | ||||
| 8. Round | 18/02/2021 | Progreso | - | Nacional | 0:1 | ||||
| 14. Round | 25/03/2021 | Progreso | - | Peñarol | 0:2 | ||||
| 15. Round | 29/03/2021 | River Plate | - | Progreso | 3:2 |
Uruguay