| 4. Round | 22/02/2025 | Boston River | - | Nacional | 2:3 |  |
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| 5. Round | 09/03/2025 | Progreso | - | Boston River | 2:2 | ||||
| 6. Round | 18/03/2025 | River Plate | - | Boston River | 0:2 | ||||
| 7. Round | 22/03/2025 | Boston River | - | Racing | 1:3 | |
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| 8. Round | 26/03/2025 | Plaza Colonia | - | Boston River | 0:1 | ||||
| 9. Round | 29/03/2025 | Boston River | - | Liverpool | 0:1 | |
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| 10. Round | 05/04/2025 | Juventud de Las Piedras | - | Boston River | 4:1 | ||||
| 11. Round | 13/04/2025 | Boston River | - | Cerro Largo | 1:0 | ||||
| 12. Round | 18/04/2025 | Danubio | - | Boston River | 1:2 | ||||
| 13. Round | 27/04/2025 | Boston River | - | Miramar Misiones | 2:0 | ||||
| 14. Round | 02/05/2025 | Boston River | - | Montevideo Wanderers | 1:0 |
Uruguay