| Group B | 14/06/2022 | Plaza Colonia | - | Boston River | 0:0 | ||||
| Group B | 20/06/2022 | Boston River | - | Danubio | 2:0 | ||||
| Group B | 26/06/2022 | River Plate | - | Boston River | 0:1 | ||||
| Group B | 16/07/2022 | Boston River | - | Cerrito | 1:0 | ||||
| Group B | 20/07/2022 | Boston River | - | Cerro Largo | 2:0 | ||||
| Group B | 24/07/2022 | Nacional | - | Boston River | 2:0 |
Uruguay