1. Round | 13/08/2021 | SK Deinze | - | Lierse Kempenzonen | 1:1 | ||||
2. Round | 22/08/2021 | Lierse Kempenzonen | - | Excelsior Virton | 2:0 | ||||
3. Round | 28/08/2021 | KVC Westerlo | - | Lierse Kempenzonen | 3:2 | ||||
4. Round | 12/09/2021 | Lierse Kempenzonen | - | RWDM Brussels FC | 4:1 | ||||
5. Round | 19/09/2021 | Lommel SK | - | Lierse Kempenzonen | 3:1 | ||||
6. Round | 24/09/2021 | Lierse Kempenzonen | - | Waasland-Beveren | 2:1 | ||||
7. Round | 02/10/2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
8. Round | 16/10/2021 | Excelsior Virton | - | Lierse Kempenzonen | 2:1 | ||||
9. Round | 23/10/2021 | Lierse Kempenzonen | - | SK Deinze | 2:2 | ||||
11. Round | 07/11/2021 | RWDM Brussels FC | - | Lierse Kempenzonen | 3:3 | ||||
12. Round | 20/11/2021 | Lierse Kempenzonen | - | KVC Westerlo | 1:5 | ||||
13. Round | 28/11/2021 | Royal Excel Mouscron | - | Lierse Kempenzonen | 2:1 | ||||
14. Round | 05/12/2021 | Lierse Kempenzonen | - | Lommel SK | 2:2 | ||||
15. Round | 12/12/2021 | Excelsior Virton | - | Lierse Kempenzonen | 2:2 | ||||
16. Round | 19/12/2021 | Lierse Kempenzonen | - | RWDM Brussels FC | 0:1 |