| 1. Round | 08/08/2020 | MFK Ružomberok | - | AS Trenčín | 2:2 |  |
|||
| 2. Round | 11/08/2020 | Spartak Trnava | - | MFK Ružomberok | 3:1 | ||||
| 3. Round | 15/08/2020 | MFK Ružomberok | - | ŠKF Sereď | 0:0 | ||||
| 4. Round | 22/08/2020 | FC Nitra | - | MFK Ružomberok | 1:1 | ||||
| 10. Round | 17/10/2020 | FK Senica | - | MFK Ružomberok | 1:2 | ||||
| 11. Round | 24/10/2020 | MFK Ružomberok | - | MŠK Žilina | 2:1 | ||||
| 12. Round | 01/11/2020 | AS Trenčín | - | MFK Ružomberok | 3:1 | ||||
| 13. Round | 07/11/2020 | MFK Ružomberok | - | Spartak Trnava | 0:1 | ||||
| 14. Round | 21/11/2020 | ŠKF Sereď | - | MFK Ružomberok | 0:0 | |
|||
| 15. Round | 28/11/2020 | MFK Ružomberok | - | FC Nitra | 3:0 | ||||
| 16. Round | 05/12/2020 | FK Pohronie | - | MFK Ružomberok | 2:2 | |
|||
| 17. Round | 12/12/2020 | MFK Ružomberok | - | FC DAC 1904 | 1:1 | ||||
| 18. Round | 16/12/2020 | MFK Zemplín Michalovce | - | MFK Ružomberok | 4:3 | ||||
| 19. Round | 13/02/2021 | MFK Ružomberok | - | Slovan Bratislava | 0:0 | ||||
| 20. Round | 20/02/2021 | Zlaté Moravce | - | MFK Ružomberok | 3:1 | ||||
| 21. Round | 27/02/2021 | MFK Ružomberok | - | FK Senica | 2:3 | ||||
| 22. Round | 06/03/2021 | MŠK Žilina | - | MFK Ružomberok | 3:2 |
Slovakia