| 1. Round | 20/09/2021 | Deportivo Dongu | - | Montañeses FC | 2:3 | ||||
| 3. Round | 02/10/2021 | Deportivo Dongu | - | Sporting Canamy | 1:2 | ||||
| 4. Round | 10/10/2021 | Yalmakan FC | - | Deportivo Dongu | 0:1 | ||||
| 11. Round | 14/11/2021 | Cafetaleros de Chiapas | - | Deportivo Dongu | 4:0 | ||||
| 12. Round | 20/11/2021 | Deportivo Dongu | - | CD Zap | 0:2 |  |
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| 13. Round | 27/11/2021 | Inter de Querétaro | - | Deportivo Dongu | 3:0 |
Mexico