1. Round | 11/09/2021 | Panetolikos | - | Asteras Tripolis | 0:0 | ||||
2. Round | 19/09/2021 | Atromitos | - | Panetolikos | 1:2 | ||||
3. Round | 22/09/2021 | Panetolikos | - | PAOK Saloniki | 1:2 | ||||
6. Round | 17/10/2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
7. Round | 24/10/2021 | Aris Saloniki | - | Panetolikos | 5:1 | ||||
8. Round | 30/10/2021 | Panetolikos | - | Olympiakos Piraeus | 1:2 | ||||
9. Round | 06/11/2021 | PAS Giannina | - | Panetolikos | 3:0 | ||||
10. Round | 21/11/2021 | Panetolikos | - | Apollon Smyrnis | 1:0 | ||||
14. Round | 14/12/2021 | Asteras Tripolis | - | Panetolikos | 1:0 | ||||
15. Round | 18/12/2021 | Panetolikos | - | Atromitos | 2:1 | ||||
16. Round | 12/01/2022 | PAOK Saloniki | - | Panetolikos | 2:0 | ||||
18. Round | 16/01/2022 | AEK Athen | - | Panetolikos | 1:2 | ||||
19. Round | 22/01/2022 | OFI Heraklion | - | Panetolikos | 2:4 | ||||
20. Round | 30/01/2022 | Panetolikos | - | Aris Saloniki | 0:2 | ||||
22. Round | 05/02/2022 | Panetolikos | - | PAS Giannina | 0:1 | ||||
23. Round | 12/02/2022 | Apollon Smyrnis | - | Panetolikos | 0:0 | ||||
17. Round | 16/02/2022 | Panetolikos | - | Lamia | 1:0 | ||||
24. Round | 19/02/2022 | Panetolikos | - | Panathinaikos | 1:0 | ||||
25. Round | 26/02/2022 | Panetolikos | - | Volos NFC | 0:0 |