| 1. Round | 26/07/2015 | CS Petrocub | - | Speranţa Nisporeni | 0:4 |  |
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| 2. Round | 01/08/2015 | FC Academia UTM | - | Speranţa Nisporeni | 2:3 | ||||
| 4. Round | 15/08/2015 | FC Milsami | - | Speranţa Nisporeni | 5:0 | ||||
| 5. Round | 23/08/2015 | Speranţa Nisporeni | - | FC Zimbru | 0:0 | ||||
| 6. Round | 28/08/2015 | Dinamo-Auto | - | Speranţa Nisporeni | 3:1 | ||||
| 7. Round | 12/09/2015 | Speranţa Nisporeni | - | FC Zaria | 0:2 | ||||
| 8. Round | 19/09/2015 | Dacia Chişinău | - | Speranţa Nisporeni | 1:1 | ||||
| 10. Round | 03/10/2015 | Speranţa Nisporeni | - | CS Petrocub | 1:1 | ||||
| 11. Round | 17/10/2015 | Speranţa Nisporeni | - | FC Academia UTM | 2:0 | |
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| 12. Round | 23/10/2015 | FC Sheriff | - | Speranţa Nisporeni | 2:1 | |
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| 13. Round | 01/11/2015 | Speranţa Nisporeni | - | FC Milsami | 1:0 | ||||
| 14. Round | 07/11/2015 | FC Zimbru | - | Speranţa Nisporeni | 0:1 | ||||
| 15. Round | 21/11/2015 | Speranţa Nisporeni | - | Dinamo-Auto | 3:2 | ||||
| 17. Round | 05/03/2016 | Speranţa Nisporeni | - | Dacia Chişinău | 0:1 | ||||
| 19. Round | 18/03/2016 | Speranţa Nisporeni | - | FC Milsami | 0:4 |  |
Moldova