| 20. Round | 20/02/2022 | APS Zakynthos | - | Irodotos | 1:0 | ||||
| 12. Round | 23/02/2022 | APS Zakynthos | - | Ergotelis | 2:0 | ||||
| 21. Round | 27/02/2022 | Levadiakos | - | APS Zakynthos | 4:0 | ||||
| 22. Round | 06/03/2022 | APS Zakynthos | - | AS Rhodos | 0:3 dec. |  |
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| 23. Round | 09/03/2022 | AO Episkopi | - | APS Zakynthos | 1:0 |  |
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| 24. Round | 13/03/2022 | APS Zakynthos | - | AE Kifisias | 1:1 | ||||
| 17. Round | 16/03/2022 | APS Zakynthos | - | OFI Ierapetra | 1:1 | ||||
| 25. Round | 19/03/2022 | AEK Athen II | - | APS Zakynthos | 1:0 | ||||
| 26. Round | 27/03/2022 | APS Zakynthos | - | PS Kalamata | 1:1 | ||||
| 27. Round | 30/03/2022 | Panathinaikos II | - | APS Zakynthos | 1:1 | |
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| 28. Round | 03/04/2022 | APS Zakynthos | - | AE Karaiskakis | 2:0 | ||||
| 29. Round | 06/04/2022 | Ergotelis | - | APS Zakynthos | 1:0 | ||||
| 30. Round | 10/04/2022 | APS Zakynthos | - | Asteras Vlachioti | 1:1 | ||||
| 31. Round | 13/04/2022 | Diagoras FC | - | APS Zakynthos | 2:0 | ||||
| 32. Round | 17/04/2022 | APS Zakynthos | - | PAE Chania | 3:1 | ||||
| 34. Round | 01/05/2022 | OFI Ierapetra | - | APS Zakynthos | 5:1 |
Greece