| 4. Round | 07/08/2024 | Sportivo Ameliano | - | Guaraní | 2:2 | ||||
| 5. Round | 11/08/2024 | Guaraní | - | 2 de Mayo | 0:0 | ||||
| 6. Round | 16/08/2024 | Sportivo Luqueño | - | Guaraní | 2:1 | ||||
| 7. Round | 24/08/2024 | Guaraní | - | General Caballero DJLM | 1:1 | ||||
| 8. Round | 28/08/2024 | Sol de América | - | Guaraní | 0:0 | ||||
| 9. Round | 01/09/2024 | Guaraní | - | Cerro Porteño | 1:0 |  |
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| 10. Round | 14/09/2024 | Tacuary | - | Guaraní | 1:2 | ||||
| 11. Round | 17/09/2024 | Guaraní | - | Club Nacional | 0:0 | ||||
| 12. Round | 23/09/2024 | Guaraní | - | Club Olimpia | 0:0 | ||||
| 13. Round | 28/09/2024 | Guaraní | - | Sportivo Trinidense | 0:0 | ||||
| 14. Round | 06/10/2024 | Libertad | - | Guaraní | 0:2 | ||||
| 15. Round | 12/10/2024 | Guaraní | - | Sportivo Ameliano | 1:1 | ||||
| 16. Round | 21/10/2024 | 2 de Mayo | - | Guaraní | 1:2 | ||||
| 17. Round | 28/10/2024 | Guaraní | - | Sportivo Luqueño | 2:2 | ||||
| 18. Round | 02/11/2024 | General Caballero DJLM | - | Guaraní | 0:0 | |
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| 20. Round | 16/11/2024 | Cerro Porteño | - | Guaraní | 1:2 | |
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| 21. Round | 24/11/2024 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Round | 29/11/2024 | Club Nacional | - | Guaraní | 0:0 |
Paraguay