| 1. Round | 04/06/2022 | River Plate II | - | Defensa y Justicia II | 2:0 | ||||
| 2. Round | 09/06/2022 | Atlético Tucumán II | - | River Plate II | 1:0 | ||||
| 3. Round | 14/06/2022 | River Plate II | - | Colón de Santa Fe II | 0:2 | ||||
| 5. Round | 24/06/2022 | Lanús II | - | River Plate II | 1:5 | ||||
| 7. Round | 09/07/2022 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 11. Round | 30/07/2022 | Sarmiento de Junín II | - | River Plate II | 0:1 | ||||
| 14. Round | 16/08/2022 | River Plate II | - | Arsenal de Sarandí II | 0:0 | ||||
| 16. Round | 28/08/2022 | River Plate II | - | Tigre II | 0:2 | ||||
| 17. Round | 03/09/2022 | Barracas Central II | - | River Plate II | 2:1 |
Argentina