| 3. Round | 06/08/2021 | Club Necaxa [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 5. Round | 18/08/2021 | Cruz Azul [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 6. Round | 21/08/2021 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 7. Round | 29/08/2021 | Cruz Azul [U20] | - | CF Pachuca [U20] | 0:0 | ||||
| 10. Round | 24/09/2021 | Puebla FC [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 |  |
Mexico