| 1. Round | 05/02/2025 | Real Hope | - | Cruz Azul | 0:2 | ||||
| 1. Round | 12/02/2025 | Cruz Azul | - | Real Hope | 5:0 | ||||
| Round of 16 | 06/03/2025 | Seattle Sounders | - | Cruz Azul | 0:0 | ||||
| Round of 16 | 12/03/2025 | Cruz Azul | - | Seattle Sounders | 4:1 | ||||
| Quarter-finals | 02/04/2025 | CF América | - | Cruz Azul | 0:0 | ||||
| Semi-finals | 24/04/2025 | UANL Tigres | - | Cruz Azul | 1:1 | ||||
| Final | 02/06/2025 | Cruz Azul | - | Vancouver Whitecaps | 5:0 |
Mexico