| 4. Round | 14/08/2021 | Cruz Azul [U20] | - | Deportivo Toluca [U20] | 2:2 | ||||
| 7. Round | 29/08/2021 | Cruz Azul [U20] | - | CF Pachuca [U20] | 0:0 | ||||
| 9. Round | 19/09/2021 | Cruz Azul [U20] | - | Gallos Blancos [U20] | 1:1 | ||||
| 10. Round | 24/09/2021 | Puebla FC [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 11. Round | 03/11/2021 | Cruz Azul [U20] | - | Club León [U20] | 2:0 | ||||
| 17. Round | 07/11/2021 | Pumas UNAM [U20] | - | Cruz Azul [U20] | 1:2 |
Mexico