| 4. Round | 09/10/2021 | Club Calor | - | Alebrijes de Oaxaca II | 1:2 | ||||
| 8. Round | 29/10/2021 | Alebrijes de Oaxaca II | - | CD Cuautla | 1:1 |  |
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| 10. Round | 11/11/2021 | Huracanes Izcalli | - | Alebrijes de Oaxaca II | 3:1 | ||||
| 11. Round | 15/11/2021 | Alebrijes de Oaxaca II | - | Club Calor | 2:1 | ||||
| 12. Round | 20/11/2021 | Aguacateros CDU | - | Alebrijes de Oaxaca II | 4:0 |
Mexico