| 1. Round | 24/01/2016 | General Díaz | - | Sportivo Luqueño | 2:2 | ||||
| 4. Round | 07/02/2016 | Club Rubio Ñu | - | General Díaz | 0:0 |  |
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| 5. Round | 12/02/2016 | General Díaz | - | Club Olimpia | 4:1 |  |
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| 9. Round | 06/03/2016 | General Díaz | - | Deportivo Capiatá | 2:2 | |
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| 10. Round | 11/03/2016 | General Díaz | - | River Plate | 3:0 | |
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| 11. Round | 20/03/2016 | Cerro Porteño | - | General Díaz | 2:2 | ||||
| 3. Round | 26/03/2016 | General Díaz | - | Guaraní | 3:2 | |
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| 12. Round | 01/04/2016 | Sportivo Luqueño | - | General Díaz | 2:0 | |
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| 14. Round | 11/04/2016 | Guaraní | - | General Díaz | 3:0 |  |
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| 17. Round | 27/04/2016 | General Díaz | - | Sol de América | 2:1 | |
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| 18. Round | 02/05/2016 | Libertad | - | General Díaz | 2:1 | ||||
| 19. Round | 04/05/2016 | General Díaz | - | Club Nacional | 1:1 | ||||
| 20. Round | 09/05/2016 | Deportivo Capiatá | - | General Díaz | 2:1 | ||||
| 22. Round | 21/05/2016 | General Díaz | - | Cerro Porteño | 2:5 |
Argentina