| 8. Round | 08/11/2020 | Zitácuaro | - | Club Irapuato | 0:0 |  |
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| 9. Round | 13/11/2020 | Club Irapuato | - | Azores de Hidalgo | 5:0 |  |
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| 2. Round | 18/11/2020 | CD Cuautla | - | Club Irapuato | 1:3 | ||||
| 11. Round | 27/11/2020 | Inter Playa | - | Club Irapuato | 2:0 | ||||
| 7. Round | 02/12/2020 | Club Irapuato | - | Cafetaleros de Chiapas | 4:2 | ||||
| 12. Round | 06/12/2020 | Club Irapuato | - | Club de Ciervos | 0:0 | |
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| 13. Round | 11/12/2020 | Cañoneros Marina | - | Club Irapuato | 1:2 | ||||
| 1. Round | 16/12/2020 | Club Irapuato | - | Cruz Azul Hidalgo | 0:2 |
Mexico