| 1. Round | 30/01/2010 | Tacuary | - | Cerro Porteño | 1:2 |  |
|||
| 2. Round | 07/02/2010 | Club Olimpia | - | Tacuary | 3:2 | |
|||
| 3. Round | 12/02/2010 | Tacuary | - | Libertad | 0:4 | ||||
| 4. Round | 17/02/2010 | Guaraní | - | Tacuary | 5:2 |  |
|||
| 7. Round | 06/03/2010 | Sportivo Luqueño | - | Tacuary | 3:3 | ||||
| 8. Round | 12/03/2010 | Tacuary | - | Sol de América | 1:1 | ||||
| 10. Round | 21/03/2010 | Tacuary | - | 3 de Febrero | 3:0 | ||||
| 11. Round | 28/03/2010 | Sport Colombia | - | Tacuary | 0:0 | ||||
| 14. Round | 22/04/2010 | Libertad | - | Tacuary | 0:0 |  |
|||
| 16. Round | 25/04/2010 | Club Rubio Ñu | - | Tacuary | 3:1 | |
|||
| 17. Round | 02/05/2010 | Sportivo Trinidense | - | Tacuary | 0:1 | ||||
| 18. Round | 08/05/2010 | Tacuary | - | Sportivo Luqueño | 1:2 | ||||
| 19. Round | 12/05/2010 | Sol de América | - | Tacuary | 1:0 | ||||
| 20. Round | 16/05/2010 | Tacuary | - | Club Nacional | 0:3 | ||||
| 22. Round | 28/05/2010 | Tacuary | - | Sport Colombia | 2:2 |
Paraguay