| 1. Round | 29/07/2000 | EA Guingamp | - | AS Saint-Étienne | 2:2 |  |
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| 4. Round | 19/08/2000 | AS Saint-Étienne | - | Girondins Bordeaux | 1:0 | ||||
| 8. Round | 17/09/2000 | AS Saint-Étienne | - | Lille OSC | 1:1 | ||||
| 9. Round | 23/09/2000 | RC Strasbourg | - | AS Saint-Étienne | 3:2 | ||||
| 10. Round | 30/09/2000 | AS Saint-Étienne | - | Stade Rennais | 0:2 | |
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| 16. Round | 18/11/2000 | RC Lens | - | AS Saint-Étienne | 0:0 | ||||
| 18. Round | 29/11/2000 | Olympique Marseille | - | AS Saint-Étienne | 2:1 | ||||
| 23. Round | 13/01/2001 | AS Saint-Étienne | - | Paris Saint-Germain | 1:0 | ||||
| 24. Round | 27/01/2001 | Lille OSC | - | AS Saint-Étienne | 4:1 | ||||
| 26. Round | 06/02/2001 | Stade Rennais | - | AS Saint-Étienne | 3:0 | ||||
| 27. Round | 17/02/2001 | AS Saint-Étienne | - | CS Sedan | 0:2 | ||||
| 30. Round | 07/04/2001 | ESTAC Troyes | - | AS Saint-Étienne | 0:0 | ||||
| 32. Round | 28/04/2001 | AS Saint-Étienne | - | RC Lens | 1:1 | ||||
| 33. Round | 12/05/2001 | FC Nantes | - | AS Saint-Étienne | 1:0 |
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