| 4. Round | 12/08/2018 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 3:0 | ||||
| 6. Round | 22/08/2018 | Club Tijuana [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 7. Round | 27/08/2018 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:0 | ||||
| 8. Round | 02/09/2018 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 3:2 | ||||
| 3. Round | 08/09/2018 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 | ||||
| 9. Round | 14/09/2018 | Santos Laguna [U20] | - | Club León [U20] | 3:4 |  |
|||
| 1. Round | 19/09/2018 | Santos Laguna [U20] | - | Lobos BUAP [U20] | 2:0 | ||||
| 12. Round | 05/10/2018 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 4:3 | ||||
| 2. Round | 10/10/2018 | Monarcas Morelia [U20] | - | Santos Laguna [U20] | 2:0 | ||||
| 14. Round | 26/10/2018 | Santos Laguna [U20] | - | CF Monterrey [U20] | 0:2 | ||||
| 15. Round | 04/11/2018 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 1:2 |  |
|||
| 16. Round | 11/11/2018 | Santos Laguna [U20] | - | CF América [U20] | 0:0 | ||||
| 17. Round | 25/11/2018 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 4:0 |
Mexico