| 1. Round | 21/07/2018 | Cruz Azul | - | Puebla FC | 3:0 | ||||
| 6. Round | 22/08/2018 | Puebla FC | - | Atlas Guadalajara | 2:0 | ||||
| 7. Round | 25/08/2018 | CF Pachuca | - | Puebla FC | 2:0 |  |
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| 11. Round | 30/09/2018 | Pumas UNAM | - | Puebla FC | 2:2 | ||||
| 12. Round | 08/10/2018 | Puebla FC | - | Lobos BUAP | 2:2 | ||||
| 14. Round | 29/10/2018 | Club León | - | Puebla FC | 0:4 | ||||
| 15. Round | 03/11/2018 | Puebla FC | - | Deportivo Guadalajara | 2:2 | ||||
| 16. Round | 11/11/2018 | UANL Tigres | - | Puebla FC | 6:1 |
Mexico