1. Round | 16/07/2022 | Sportivo Ameliano | - | Libertad | 2:0 | ||||
2. Round | 20/07/2022 | Libertad | - | Club Olimpia | 4:2 | ||||
7. Round | 21/08/2022 | Club Nacional | - | Libertad | 0:2 | ||||
9. Round | 04/09/2022 | Cerro Porteño | - | Libertad | 1:0 | ||||
10. Round | 10/09/2022 | Guaireña FC | - | Libertad | 4:0 | ||||
14. Round | 02/10/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
15. Round | 06/10/2022 | Resistencia SC | - | Libertad | 1:0 | ||||
13. Round | 12/10/2022 | Club Olimpia | - | Libertad | 1:0 |