| 1. Round | 30/07/2022 | Plaza Colonia | - | Boston River | 1:1 | ||||
| 2. Round | 06/08/2022 | Cerrito | - | Boston River | 0:3 |  |
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| 3. Round | 12/08/2022 | Boston River | - | River Plate | 1:2 | ||||
| 4. Round | 04/09/2022 | Cerro Largo | - | Boston River | 1:1 |  |
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| 7. Round | 10/09/2022 | Boston River | - | Albion | 1:0 | ||||
| 10. Round | 23/09/2022 | Deportivo Maldonado | - | Boston River | 2:1 |
Argentina