| 2. Round | 17/01/2016 | Puebla FC | - | CF Monterrey | 1:3 | ||||
| 3. Round | 24/01/2016 | Pumas UNAM | - | Puebla FC | 0:1 | ||||
| 4. Round | 31/01/2016 | Deportivo Toluca | - | Puebla FC | 1:1 | ||||
| 5. Round | 07/02/2016 | Puebla FC | - | Atlas Guadalajara | 4:1 |  |
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| 6. Round | 15/02/2016 | CF Pachuca | - | Puebla FC | 5:2 | ||||
| 7. Round | 21/02/2016 | Puebla FC | - | Dorados de Sinaloa | 3:2 | ||||
| 12. Round | 03/04/2016 | Monarcas Morelia | - | Puebla FC | 2:0 | ||||
| 13. Round | 10/04/2016 | Puebla FC | - | Deportivo Guadalajara | 0:3 | |
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| 14. Round | 17/04/2016 | Club León | - | Puebla FC | 4:1 |
Uruguay