| 1. Round | 01/08/2022 | Liverpool | - | Defensor Sporting | 1:3 |  |
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| 2. Round | 07/08/2022 | Defensor Sporting | - | Peñarol | 2:3 | ||||
| 3. Round | 14/08/2022 | Montevideo City Torque | - | Defensor Sporting | 0:2 | ||||
| 6. Round | 21/08/2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Round | 28/08/2022 | Plaza Colonia | - | Defensor Sporting | 0:1 |  |
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| 8. Round | 16/09/2022 | Defensor Sporting | - | Cerro Largo | 0:1 | ||||
| 15. Round | 22/10/2022 | Defensor Sporting | - | Rentistas | 2:3 |
Uruguay