| 1. Round | 13/03/2022 | Birmingham Legion | - | Tampa Bay Rowdies | 1:1 | ||||
| 1. Round | 20/03/2022 | FC Tulsa | - | Birmingham Legion | 3:1 | ||||
| 1. Round | 26/03/2022 | Birmingham Legion | - | Colorado Springs Switchbacks | 0:2 | ||||
| 2. Round | 03/04/2022 | Birmingham Legion | - | Louisville City FC | 0:0 | ||||
| 2. Round | 10/04/2022 | Birmingham Legion | - | Hartford Athletic | 2:1 | ||||
| 2. Round | 16/04/2022 | Detroit City FC | - | Birmingham Legion | 1:0 | ||||
| 2. Round | 24/04/2022 | Loudoun United | - | Birmingham Legion | 1:2 |  |
Senegal