1. Round | 25/07/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
3. Round | 08/08/2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
6. Round | 22/08/2021 | Pumas UNAM | - | Puebla FC | 2:0 | ||||
7. Round | 29/08/2021 | Deportivo Toluca | - | Pumas UNAM | 2:1 | ||||
8. Round | 12/09/2021 | Pumas UNAM | - | Deportivo Guadalajara | 0:0 | ||||
15. Round | 24/10/2021 | Pumas UNAM | - | Club Tijuana | 3:1 |