| 3. Round | 07/08/2021 | FK Biolog Novokubansk | - | FK Legion Dynamo Makhachkala | 0:0 | ||||
| 4. Round | 15/08/2021 | FK Mashuk KMV | - | FK Biolog Novokubansk | 2:0 | ||||
| 5. Round | 18/08/2021 | FK Biolog Novokubansk | - | Spartak Nalchik | 1:0 | ||||
| 6. Round | 29/08/2021 | FK Chayka | - | FK Biolog Novokubansk | 2:1 | ||||
| 8. Round | 08/09/2021 | FK Druzhba | - | FK Biolog Novokubansk | 1:1 |  |
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| 11. Round | 26/09/2021 | FK Biolog Novokubansk | - | Forte Taganrog | 0:0 | |
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| 12. Round | 03/10/2021 | FK Dinamo Makhachkala | - | FK Biolog Novokubansk | 2:0 |
Georgia
Russia