| 1. Round | 24/07/2021 | FK Dinamo Makhachkala | - | FK Druzhba | 3:0 | ||||
| 3. Round | 07/08/2021 | FK Tuapse | - | FK Druzhba | 3:0 | ||||
| 6. Round | 29/08/2021 | FK Druzhba | - | Chernomorets Novorossisk | 0:1 | ||||
| 7. Round | 04/09/2021 | FK Yessentuki | - | FK Druzhba | 2:1 | ||||
| 17. Round | 06/11/2021 | FK Druzhba | - | Forte Taganrog | 1:2 | ||||
| 21. Round | 06/04/2022 | FK Druzhba | - | Dinamo Stavropol | 4:1 | ||||
| 25. Round | 10/04/2022 | FK Druzhba | - | FK Legion Dynamo Makhachkala | 1:1 |  |
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| 28. Round | 30/04/2022 | FK Chayka | - | FK Druzhba | 3:0 | ||||
| 29. Round | 06/05/2022 | FK Druzhba | - | Anzhi Makhachkala | 2:2 | ||||
| 31. Round | 16/05/2022 | Alania-2 Vladikavkaz | - | FK Druzhba | 1:2 | ||||
| 33. Round | 29/05/2022 | Forte Taganrog | - | FK Druzhba | 1:0 | ||||
| 34. Round | 05/06/2022 | FK Druzhba | - | FK Dinamo Makhachkala | 1:2 | |
Russia