16. Round | 28/11/2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
17. Round | 05/12/2021 | MŠK Žilina | - | Spartak Trnava | 0:1 | ||||
18. Round | 10/12/2021 | Spartak Trnava | - | MFK Zemplín Michalovce | 2:0 | ||||
19. Round | 18/12/2021 | ŠKF Sereď | - | Spartak Trnava | 0:1 | ||||
20. Round | 13/02/2022 | Spartak Trnava | - | FC DAC 1904 | 1:1 | ||||
21. Round | 19/02/2022 | Spartak Trnava | - | AS Trenčín | 0:0 |