| 18. Round | 31/01/2022 | KF Laçi | - | FK Partizani | 1:0 |  |
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| 19. Round | 05/02/2022 | KF Teuta Durrës | - | FK Partizani | 0:4 | ||||
| 20. Round | 14/02/2022 | KF Skënderbeu | - | FK Partizani | 1:2 | |
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| 21. Round | 19/02/2022 | FK Partizani | - | FK Vllaznia | 1:1 | ||||
| 22. Round | 25/02/2022 | Dinamo Tiranë | - | FK Partizani | 0:0 | ||||
| 24. Round | 05/03/2022 | KF Tiranë | - | FK Partizani | 0:0 | |
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| 25. Round | 12/03/2022 | FK Partizani | - | Egnatia Rrogozhine | 2:2 | ||||
| 26. Round | 19/03/2022 | KS Kastrioti | - | FK Partizani | 1:0 | ||||
| 27. Round | 04/04/2022 | FK Partizani | - | KF Laçi | 2:1 | |
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| 29. Round | 17/04/2022 | FK Partizani | - | KF Skënderbeu | 0:0 | ||||
| 30. Round | 23/04/2022 | FK Vllaznia | - | FK Partizani | 0:0 | ||||
| 31. Round | 29/04/2022 | FK Partizani | - | Dinamo Tiranë | 3:1 | ||||
| 32. Round | 03/05/2022 | FK Kukësi | - | FK Partizani | 1:2 | |
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| 33. Round | 07/05/2022 | FK Partizani | - | KF Tiranë | 1:2 | ||||
| 34. Round | 14/05/2022 | Egnatia Rrogozhine | - | FK Partizani | 0:1 | ||||
| 35. Round | 21/05/2022 | FK Partizani | - | KS Kastrioti | 4:0 | ||||
| 36. Round | 26/05/2022 | KF Laçi | - | FK Partizani | 3:4 | |
Albania