| 10. Round | 26/10/1980 | SBV Excelsior | - | Willem II | 0:2 | ||||
| 11. Round | 01/11/1980 | Willem II | - | FC Groningen | 4:1 | ||||
| 12. Round | 07/11/1980 | FC Den Haag | - | Willem II | 0:1 | ||||
| 13. Round | 22/11/1980 | Willem II | - | AZ '67 Alkmaar | 0:2 | ||||
| 14. Round | 28/11/1980 | PEC Zwolle | - | Willem II | 3:0 | ||||
| 15. Round | 06/12/1980 | Willem II | - | SC NEC | 1:1 | ||||
| 16. Round | 13/12/1980 | AFC Ajax | - | Willem II | 1:1 | ||||
| 18. Round | 31/01/1981 | FC Twente | - | Willem II | 5:1 | ||||
| 19. Round | 07/02/1981 | Willem II | - | Feyenoord | 1:2 | ||||
| 20. Round | 14/02/1981 | Sparta Rotterdam | - | Willem II | 3:1 | ||||
| 21. Round | 27/02/1981 | Willem II | - | FC Utrecht | 0:1 | ||||
| 22. Round | 06/03/1981 | Go Ahead Eagles | - | Willem II | 4:2 | ||||
| 23. Round | 14/03/1981 | Willem II | - | Roda JC Kerkrade | 2:2 | ||||
| 17. Round | 21/03/1981 | Willem II | - | MVV | 2:1 | ||||
| 24. Round | 27/03/1981 | FC Wageningen | - | Willem II | 2:1 | ||||
| 25. Round | 04/04/1981 | Willem II | - | NAC Breda | 2:2 | ||||
| 26. Round | 10/04/1981 | PSV Eindhoven | - | Willem II | 4:0 | ||||
| 27. Round | 17/04/1981 | Willem II | - | SBV Excelsior | 2:1 | ||||
| 28. Round | 25/04/1981 | FC Groningen | - | Willem II | 0:2 | ||||
| 29. Round | 02/05/1981 | Willem II | - | FC Den Haag | 2:1 |
Netherlands