| 1. Round | 17/09/2000 | OFI Heraklion | - | Aris Saloniki | 2:3 |  |
|||
| 6. Round | 11/11/2000 | Aris Saloniki | - | Iraklis Saloniki | 0:2 | ||||
| 9. Round | 02/12/2000 | Aris Saloniki | - | Ionikos Nikea | 0:0 | ||||
| 11. Round | 16/12/2000 | Aris Saloniki | - | Panachaiki GE | 0:0 | ||||
| 13. Round | 06/01/2001 | Aris Saloniki | - | PAS Giannina | 1:0 | ||||
| 14. Round | 13/01/2001 | Panionios GSS | - | Aris Saloniki | 2:0 | ||||
| 15. Round | 20/01/2001 | Olympiakos Piraeus | - | Aris Saloniki | 4:1 | |
|||
| 16. Round | 26/01/2001 | Aris Saloniki | - | OFI Heraklion | 2:0 | |
|||
| 18. Round | 09/02/2001 | Aris Saloniki | - | Panathinaikos | 1:0 | ||||
| 19. Round | 16/02/2001 | PAOK Saloniki | - | Aris Saloniki | 2:0 | |
|||
| 21. Round | 02/03/2001 | Iraklis Saloniki | - | Aris Saloniki | 1:2 | |
|||
| 22. Round | 10/03/2001 | Athinaikos | - | Aris Saloniki | 2:0 | ||||
| 23. Round | 17/03/2001 | Aris Saloniki | - | Ethnikos Asteras | 2:0 | ||||
| 24. Round | 01/04/2001 | Ionikos Nikea | - | Aris Saloniki | 2:1 | |
|||
| 27. Round | 28/04/2001 | Aris Saloniki | - | PS Kalamata | 3:2 | |
Greece