| 1. Round | 07/11/2021 | AO Episkopi | - | AE Karaiskakis | 0:1 |  |
|||
| 2. Round | 13/11/2021 | AE Karaiskakis | - | AE Kifisias | 0:2 | ||||
| 3. Round | 20/11/2021 | AEK Athen II | - | AE Karaiskakis | 2:1 | ||||
| 4. Round | 24/11/2021 | AE Karaiskakis | - | PS Kalamata | 0:1 | ||||
| 5. Round | 27/11/2021 | Panathinaikos II | - | AE Karaiskakis | 2:2 | ||||
| 7. Round | 11/12/2021 | AE Karaiskakis | - | Ergotelis | 3:2 | |
|||
| 8. Round | 15/12/2021 | Asteras Vlachioti | - | AE Karaiskakis | 1:1 | ||||
| 9. Round | 19/12/2021 | AE Karaiskakis | - | Diagoras FC | 0:0 |  |
|||
| 10. Round | 29/12/2021 | PAE Chania | - | AE Karaiskakis | 4:0 | ||||
| 14. Round | 16/01/2022 | AO Egaleo | - | AE Karaiskakis | 1:0 | ||||
| 15. Round | 23/01/2022 | AE Karaiskakis | - | Irodotos | 2:1 | |
|||
| 11. Round | 26/01/2022 | AE Karaiskakis | - | APS Zakynthos | 0:2 |
Greece