| Group D | 26/03/2021 | Panama | - | Barbados | 1:0 | ||||
| Group D | 28/03/2021 | Dominica | - | Panama | 1:2 | ||||
| Group D | 09/06/2021 | Panama | - | Dom. Republic | 3:0 | ||||
| 2. Round | 13/06/2021 | Panama | - | Curaçao | 2:1 | ||||
| 2. Round | 16/06/2021 | Curaçao | - | Panama | 0:0 | ||||
| 3. Round | 03/09/2021 | Panama | - | Costa Rica | 0:0 | ||||
| 3. Round | 05/09/2021 | Jamaica | - | Panama | 0:3 |  |
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| 3. Round | 09/09/2021 | Panama | - | Mexico | 1:1 | ||||
| 3. Round | 13/11/2021 | Honduras | - | Panama | 2:3 | ||||
| 3. Round | 17/11/2021 | Panama | - | El Salvador | 2:1 | ||||
| 3. Round | 28/01/2022 | Costa Rica | - | Panama | 1:0 | ||||
| 3. Round | 30/01/2022 | Panama | - | Jamaica | 3:2 | ||||
| 3. Round | 25/03/2022 | Panama | - | Honduras | 1:1 | ||||
| 3. Round | 28/03/2022 | USA | - | Panama | 5:1 |
Panama