| 1. Round | 06/01/2022 | Club Celaya | - | Tepatitlán | 1:1 | ||||
| 2. Round | 12/01/2022 | Cancún FC | - | Club Celaya | 2:0 | ||||
| 9. Round | 23/02/2022 | Club Celaya | - | Correcaminos UAT | 1:1 | ||||
| 10. Round | 01/03/2022 | Alebrijes de Oaxaca | - | Club Celaya | 1:0 |  |
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| 11. Round | 08/03/2022 | Club Celaya | - | Atlético Morelia | 2:2 | ||||
| 12. Round | 17/03/2022 | Cimarrones de Sonora | - | Club Celaya | 3:2 | ||||
| 13. Round | 23/03/2022 | Dorados de Sinaloa | - | Club Celaya | 0:2 | |
Mexico