| 1. Round | 06/08/2005 | Rosario Central | - | Olimpo de Bahía Blanca | 1:1 |  |
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| 2. Round | 14/08/2005 | Boca Juniors | - | Rosario Central | 2:2 | ||||
| 3. Round | 21/08/2005 | Rosario Central | - | Gimnasia de Jujuy | 3:2 | ||||
| 5. Round | 08/09/2005 | Instituto de Córdoba | - | Rosario Central | 0:0 |  |
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| 6. Round | 11/09/2005 | Rosario Central | - | San Lorenzo | 0:4 | |
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| 7. Round | 18/09/2005 | Argentinos Juniors | - | Rosario Central | 1:0 | ||||
| 8. Round | 24/09/2005 | Rosario Central | - | Gimnasia de La Plata | 0:3 | |
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| 9. Round | 02/10/2005 | Racing Club | - | Rosario Central | 0:1 | ||||
| 12. Round | 30/10/2005 | Rosario Central | - | River Plate | 0:3 | ||||
| 13. Round | 06/11/2005 | Newell's Old Boys | - | Rosario Central | 2:1 | ||||
| 14. Round | 11/11/2005 | Rosario Central | - | Banfield | 0:0 | ||||
| 15. Round | 17/11/2005 | Colón de Santa Fe | - | Rosario Central | 2:0 | |
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| 17. Round | 27/11/2005 | Vélez Sarsfield | - | Rosario Central | 0:2 | ||||
| 19. Round | 14/12/2005 | Independiente | - | Rosario Central | 2:2 |
Argentina