| 1. Round | 27/07/2021 | Cruz Azul | - | Mazatlán FC | 0:2 | ||||
| 2. Round | 02/08/2021 | Santos Laguna | - | Cruz Azul | 1:1 |  |
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| 3. Round | 07/08/2021 | Club Necaxa | - | Cruz Azul | 1:2 | |
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| 5. Round | 19/08/2021 | Cruz Azul | - | CF Monterrey | 1:1 | ||||
| 8. Round | 11/09/2021 | FC Juárez | - | Cruz Azul | 2:1 | ||||
| 9. Round | 20/09/2021 | Cruz Azul | - | Gallos Blancos | 2:0 |
Mexico