| 2. Round | 09/07/2022 | Mazatlán FC | - | UANL Tigres | 0:1 | ||||
| 4. Round | 23/07/2022 | Mazatlán FC | - | Atlético San Luis | 1:1 | ||||
| 5. Round | 28/07/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 8. Round | 13/08/2022 | Club León | - | Mazatlán FC | 0:3 | ||||
| 10. Round | 21/08/2022 | FC Juárez | - | Mazatlán FC | 1:1 | ||||
| 16. Round | 24/09/2022 | Club Necaxa | - | Mazatlán FC | 2:2 |
Mexico