| 6. Round | 20/03/2022 | Liverpool | - | Rentistas | 1:0 | ||||
| 8. Round | 09/04/2022 | Peñarol | - | Liverpool | 2:1 | ||||
| 9. Round | 16/04/2022 | Liverpool | - | Montevideo City Torque | 2:0 |  |
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| 10. Round | 23/04/2022 | Montevideo Wanderers | - | Liverpool | 0:0 | |
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| 11. Round | 07/05/2022 | Liverpool | - | Plaza Colonia | 1:0 | ||||
| 12. Round | 16/05/2022 | Boston River | - | Liverpool | 2:3 | |
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| 13. Round | 22/05/2022 | Liverpool | - | River Plate | 2:1 | |
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| 14. Round | 28/05/2022 | Cerro Largo | - | Liverpool | 1:2 | ||||
| 15. Round | 05/06/2022 | Liverpool | - | Fénix | 1:0 | |
Uruguay