| 3. Round | 29/01/2022 | Inter de Querétaro | - | Escorpiones | 0:2 |  |
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| 4. Round | 05/02/2022 | Cafetaleros de Chiapas | - | Inter de Querétaro | 4:0 | ||||
| 7. Round | 27/02/2022 | Montañeses FC | - | Inter de Querétaro | 1:2 | ||||
| 8. Round | 05/03/2022 | Inter de Querétaro | - | Leviatán FC | 2:2 | ||||
| 9. Round | 12/03/2022 | Sporting Canamy | - | Inter de Querétaro | 2:0 | ||||
| 10. Round | 19/03/2022 | Inter de Querétaro | - | Yalmakan FC | 0:2 | ||||
| 1. Round | 23/03/2022 | Inter de Querétaro | - | Cañoneros FC | 0:1 | ||||
| 11. Round | 27/03/2022 | Lobos ULMX | - | Inter de Querétaro | 0:0 | ||||
| 12. Round | 02/04/2022 | Inter de Querétaro | - | Reboceros de La Piedad | 1:1 |
Colombia