| 13. Round | 13/08/2022 | Defensa y Justicia | - | Tigre | 0:0 |  |
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| 14. Round | 18/08/2022 | Barracas Central | - | Defensa y Justicia | 3:1 | ||||
| 15. Round | 22/08/2022 | Defensa y Justicia | - | Boca Juniors | 0:1 | ||||
| 16. Round | 27/08/2022 | Banfield | - | Defensa y Justicia | 1:2 | |
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| 17. Round | 05/09/2022 | Defensa y Justicia | - | San Lorenzo | 0:0 | ||||
| 19. Round | 15/09/2022 | Defensa y Justicia | - | Argentinos Juniors | 2:1 |  |
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| 20. Round | 20/09/2022 | Estudiantes | - | Defensa y Justicia | 1:2 | |
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| 26. Round | 18/10/2022 | Colón de Santa Fe | - | Defensa y Justicia | 1:2 | ||||
| 27. Round | 22/10/2022 | Defensa y Justicia | - | Atlético Tucumán | 3:1 |
Argentina